ACYL DERIVATIVES OF o-AMINOPHENOL.

Syntheses and antimicrobial activities of 9-O-acyl derivatives of tylosin and demycarosyltylosin.

Synthesis of novel 4,5-diphenylthiazole derivatives as potential acyl-CoA:cholesterol O-acyltransferase inhibitors.

Several novel N-(4,5-diphenylthiazol-2-yl)-N'-aryl or alkyl (thio)ureas and N-(4,5-diphenylthiazol-2-yl)alkanamides were prepared as potential acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitors. Synthesis was accomplished by reaction of 2-amino-4,5-diphenylthiazole with the suitable isocyanate, isothiocyanate or acyl chloride. Some analogues without the 5-phenyl substituent or both the p...

Electrocatalytic oxidation of formaldehyde on novel composite of nickel/triton-x100/poly(o-aminophenol-co-aniline)

Oxidation of formaldehyde (HCHO) is very important, owing to its use in fuel cells. Modification of electrodes surfaces is an excellent way to decrease the overpotentials as well as to increase the current density of the voltammetric response.pt as most efficient metal catalyst can easily be poisoned by product of oxidation and also it has high cost. In this work an efficient and low cost elect...

Synthesis, Characterization and Antibacterial Activity Studies of Some N-Acyl-N'-aryl Thiourea Derivatives

Some N¬-acyl-N'-aryl thiourea derivatives 4(a-f) have been prepared by the reaction of acyl halides ammonium thiocyanate and aryl amines. The structures of synthesized compounds have been characterized by IR, 1HNMR spectral studies. The synthesized compounds 5(a-f) have been screened for antibacterial activity. The effect of the structure of the investigated compounds on the antibacterial activ...

Ureidopyridazine Derivatives as Acyl-CoA:cholesterol acyltransferase Inhibitors

A series of N-(2,4-difluorophenyl)-N’-heptyl-N’4-[(substituted)-pyridazin-3yl)thio]pentyl urea derivatives having a phenyl ring at positions 5 and/or at position 6 of the heterocycle, as well as the corresponding sulfones, were synthesized. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studi...